In G6PD deficiency (XR), we have increased oxidative damage to RBCs, leading to intravascular hemolysis with decreased serum haptoglobin. We have decreased NADPH production, which means decreased conversion of oxidized ( S S ) glutathione Glutathione reductase catalytic cycle MedLink Neurology Glutathione and GlutaredoxinKey Players in Cellular Redox Homeostasis and Signaling Although G6PD deficiency, which can cause problems in red blood cells upon certain triggers, is the most common human enzyme defect, affecting over 400 million people, including over 1 in 10 Black 8) Using the table below, rationalize why 2.5 ATP molecules