Toxicity of Glutathione Binding Metals: A Review of Targets and Mechanisms Glutathione is a critical soldier in our line of defense. We even have mechanisms that recycle and reuse it. But what happens when our toxic burden becomes too high? Our genetic detoxification Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Too Much of a Good Thing: Inadvertent Acetaminophen Overdose in a Low Weight, Elderly Patient Figure 1: CMAJ