Cagrilintide vs Retatrutide for Weight Loss and Metabolic Health BetteryouRx Cagrilintide is a long acting amylin analog that regulates appetite, gastric emptying, and glucagon secretion to treat obesity and related metabolic disorders. There are 2 pathways cagrilintide works: #1 is the Amylin pathway Semaglutide and cagrilintide have each been shown to induce weight loss, but how these drugs work in combination in patients with type 2 diabetes and overweight or obesity is unknown. Research findings cagrilintide Cagrilintide is an amylin analogue that helps regulate appetite. In a randomized trial of over 3400 patients who were overweight or obese and had 1 weight related complication, individuals assigned to a combination