Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect Researchers are studying a possible link between acetaminophen (Tylenol) use during pregnancy and higher autism or ADHD risk. It may lower glutathione, an important antioxidant for brain development. Sex differences in glutathione metabolism and acetaminophen toxicity Figure 1: CMAJ Figure 1 from Acetaminophen toxicity and 5 oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP depleting futile cycle and the other a useful cycle. Semantic Scholar