Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model Theoretical Biology and Medical Modelling Springer Nature Link Sex differences in glutathione metabolism and acetaminophen toxicity how acetaminophen is broken down and metabolized! why you should not worry about glutathione depletion! #acetaminophen #glutathione #harvardmed #metabolism #medicine Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.