I'm taking NAC and glutathione as per my OAT and other testing says I need. Yet it makes me depressed. Anyone know why ? The mechanism of action of N acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species ScienceDirect Glutathione Precursor, N Acetyl Cysteine, Improves Mismatch Negativity in Schizophrenia Patients Neuropsychopharmacology NAcetylcysteine (NAC) is More Than Just an Antidote. NAC replenishes glutathione (GSH), breaks mucus disulfide bonds, and modulates glutamate. That's why it works in the liver, lungs, and brain. Owais Top 9 Benefits of NAC (N Acetyl Cysteine)