Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Tylenol and Glutathione: A Closer Look At Their Relationship Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Data summary: IL 4 regulates glutathione levels in the liver and lung Download Scientific Diagram Acetaminophen Toxicity and Liver Zone Physiology [#DaVinciCases GI 5 Physiology Case 3]